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What is DMPK and how does it fit into drug development ...
https://www.xenotech.com/blog/what-is-dmpk-and-how-does-it-fit-into-drug-development/
DMPK studies allow drug developers to experimentally evaluate intrinsic properties of a drug candidate to validate that it can and will be cleared from the body, when administered to a patient, without producing harmful byproducts (metabolites), reaching dangerous exposure levels (toxicity), or causing adverse side effects.
DMPK, DMPK Studies, DMPK Assay - NorthEast BioLab
https://www.nebiolab.com/drug-metabolism-and-pharmacokinetics-dmpk/
Progressive DMPK Studies And DMPK Assays To Evaluate And Enhance Your Drug's Bioavailability, Interaction, And Metabolic Profile [email protected] Email Your Inquiry (203) 361 3780 Speak to Our Scientists
DMPK ADME Studies - Charles River Laboratories
https://www.criver.com/products-services/lab-sciences/dmpk
DMPK ADME studies provide a strong understanding about the absorption, distribution, metabolism and excretion (ADME) parameters for compounds of interest and associated metabolites contributing to enhanced drug design and avoidance of DDIs while reducing attrition rate of future drug candidates.
DMPK gene: MedlinePlus Genetics
https://medlineplus.gov/genetics/gene/dmpk/
Myotonic dystrophy. Mutations in the DMPK gene cause a form of myotonic dystrophy known as myotonic dystrophy type 1. Myotonic dystrophy is characterized by progressive muscle wasting and weakness. The muscle weakness associated with type 1 particularly affects muscles farthest from the center of the body (distal muscles), such as those of the lower legs, hands, neck, and …
Drug metabolism and Pharmacokinetics in drug discovery
https://www.europeanpharmaceuticalreview.com/article/13707/evolution-of-drug-metabolism-and-pharmacokinetics-in-drug-discovery-and-development/
Drug Metabolism and Pharmacokinetics (DMPK) is a scientific discipline once primarily associated with safety evaluation in drug development that has, in the last two decades, become a core discipline within drug discovery, development and even post-marketing.
DYSTROPHIA MYOTONICA PROTEIN KINASE; DMPK
https://www.omim.org/entry/605377
A CTG repeat in DMPK is transcribed and is located in the 3-prime untranslated region (UTR) of an mRNA that is expressed in tissues affected by myotonic dystrophy (DM1; 160900). The polypeptide encoded by this mRNA is a member of the protein kinase family. Since the triplet repeat sequence is within a gene that has a sequence similar to protein ...
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