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Frontiers | Adrenergic Mechanisms of Audiogenic Seizure ...
https://www.frontiersin.org/articles/10.3389/fnins.2021.581048/full#:~:text=Using%20our%20audiogenic%20seizure%20model%2C%20we%20demonstrate%20that,is%20breathing%20recovery%20after%20initial%20tonic%20phase%20apnea.
Audiogenic seizure as a model of sudden death in …
https://pubmed.ncbi.nlm.nih.gov/31981213/
Abstract. Objective: Mouse models of sudden unexpected death in epileptic patients (SUDEP) using audiogenic seizures (AGS) are valuable because death can occur following a sound-induced seizure in the absence of any pharmacologic or electric component. However, only a few strains of mice are AGS prone, and the vast majority of studies involve DBA/2 or DBA/1 inbred …
Audiogenic Seizure - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/audiogenic-seizure
Audiogenic Seizures. AGSs are induced in a sound-isolated acoustic chamber. The acoustic stimulus is usually produced in the middle of the chamber by an electric bell (mixed sounds), or in the form of a pure tone delivered at 100–120 dB. The acoustic stimulus is presented either until a seizure is evoked, or for 60 s (whichever comes first), and the animal’s behavior is recorded on …
Audiogenic seizure as a model of sudden death in …
https://www.ncbi.nlm.nih.gov/pubmed/31981213
Audiogenic seizure as a model of sudden death in epilepsy: A comparative study between four inbred mouse strains from early life to adulthood. Martin B (1), Dieuset G (1), Pawluski JL (1), Costet N (1) (2), Biraben A (1). Author information: (1)Univ Rennes, CHU Rennes, Inserm, LTSI (Laboratoire de Traitement du Signal et de l'Image), UMR-1099, F-35000, Rennes, France.
Audiogenic Seizures - Biological Phenomenon and ...
https://www.intechopen.com/chapters/19737
Audiogenic seizures were also described in the WAG/Rij rat strain which was initially studied as the laboratory model for the “absence” epilepsy (Kuznetzova et al., 1996). Midzyanovskaya et al. (2004 ) noted that about one third of WAG/Rij rats develop audiogenic seizure fit in response to loud sound stimulation, although these seizures were of low intensity –the tonic seizure stage …
Adrenergic Mechanisms of Audiogenic Seizure-Induced …
https://pubmed.ncbi.nlm.nih.gov/33762902/
Conversely, in adult D/+ mice inhibition of adrenergic receptors converted normally non-fatal audiogenic seizures into fatal seizures. Taken together, our studies show that in our novel audiogenic seizure-induced death model adrenergic receptor activation is necessary and sufficient for recovery of breathing and prevention of seizure-induced death.
Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are ...
https://pubmed.ncbi.nlm.nih.gov/31666356/
Audiogenic seizures (AGSs) are arguably the most robust behavioral phenotype in the FXS mouse model-the Fmr1 knockout-and may be considered a model of sensory hypersensitivity in FXS. We provide the clearest and most precise genetic evidence to date for the cell types and brain regions involved in causing AGSs in the Fmr1 knockout and, more broadly, for any mouse mutant.
Audiogenic seizure as a model of sudden death in epilepsy ...
https://onlinelibrary.wiley.com/doi/full/10.1111/epi.16432
Mouse models of sudden unexpected death in epileptic patients (SUDEP) using audiogenic seizures (AGS) are valuable because death can occur following a sound‐induced seizure in the absence of any pharmacologic or electric component.
Audiogenic seizure as a model of sudden death in epilepsy ...
https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.16432?af=R
Objective Mouse models of sudden unexpected death in epileptic patients (SUDEP) using audiogenic seizures (AGS) are valuable because death can occur following a sound‐induced seizure in the absence ...
Animal models of epilepsy: use and limitations
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164293/
Audiogenic seizures. Audiogenic seizures (AS) are generalized seizures provoked by high-intensity acoustic stimulation. Activation of auditory pathways is crucial for AS development, and the inferior colliculus in the auditory midbrain plays a key role in audiogenic seizure initiation, although other structures participate in AS progression. 103, 104
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